Journal
TRENDS IN IMMUNOLOGY
Volume 25, Issue 10, Pages 518-523Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2004.08.007
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Funding
- NHLBI NIH HHS [R01HL49915] Funding Source: Medline
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The establishment of mixed hematopoietic chimerism induces life-long donor-specific organ graft tolerance while obviating the need for chronic immunosuppression. Recent advances have dramatically reduced the conditioning toxicity required to achieve mixed chimerism. We argue that the achievement of high levels of donor chimerism ensures life-long deletion of donor-reactive T cells, precluding and obviating the need for regulatory mechanisms in the maintenance of tolerance. However, in situations where high levels of donor chimerism cannot be established or sustained, control of immune responsiveness can be achieved through additional mechanisms, including regulatory T cells.
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