Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 155, Issue 1-2, Pages 161-171Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2004.06.008
Keywords
multiple sclerosis; inflammation; CXCL8; interferon-beta 1a; monocytes
Categories
Funding
- NINDS NIH HHS [NS 38213] Funding Source: Medline
Ask authors/readers for more resources
Multiple Sclerosis (MS) is a chronic inflammatory disease of the CNS which is characterized by large mononuclear cell infiltration and significant demyelination. CXCL8 is a chemo-attractant for both neutrophils and monocytes and triggers their firm adhesion to endothelium. In this study, we demonstrate that serum CXCL8 and CXCL8 secretion from PBMCs are significantly higher in untreated MS patients compared to controls and are significantly reduced in MS patients receiving interferon-beta1a therapy. We suggest that CXCL8 may serve as a marker of monocyte activity in MS and may play a role in monocyte recruitment to the CNS. (C) 2004 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available