Journal
NATURE REVIEWS IMMUNOLOGY
Volume 4, Issue 10, Pages 787-799Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri1460
Keywords
-
Categories
Ask authors/readers for more resources
Mast cells have mainly been studied in the setting of allergic disease, but the importance of mast cells for host defence against several pathogens has now been well established. The location of mast cells, which are found closely associated with blood vessels, allows them to have a crucial sentinel role in host defence. The mast cell has a unique `armamentarium' of receptor systems and mediators for responding to pathogen-associated signals. Studies of this intriguing immune-effector cell provide important insights into the complex mechanisms by which appropriate innate and acquired immune responses are initiated.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available