Journal
CLINICAL AND EXPERIMENTAL HYPERTENSION
Volume 26, Issue 7-8, Pages 629-636Publisher
TAYLOR & FRANCIS INC
DOI: 10.1081/CEH-200031948
Keywords
selective leptin resistance; sympathetic nervous system; lipotoxicity
Funding
- NHLBI NIH HHS [HL14388, HL44546] Funding Source: Medline
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Obesity is associated with increased risk of hypertension and heart disease. Leptin has recently been linked to increased risk of cardiovascular disease. We review briefly here two concepts regarding loss of leptin actions that have potential implications for cardiovascular disease. These are: 1. the concept of selective leptin resistance; and 2. the concept that loss of leptin action results in lipid accumulation and lipotoxicity of skeletal muscle, pancreatic islet cells, and heart and, thereby, promotes insulin resistance, insulin deficiency and cardiac dysfunction, respectively.
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