4.7 Article

Epigenetic tinkering and evolution: is there any continuity in the role of cytosine methylation from invertebrates to vertebrates?

Journal

CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 61, Issue 19-20, Pages 2425-2427

Publisher

BIRKHAUSER VERLAG AG
DOI: 10.1007/s00018-004-4184-y

Keywords

epigenetics; DNA methylation; DNA methyltransferase; gene expression; cytosine methylation functions; invertebrate-vertebrate transition

Ask authors/readers for more resources

The function of DNA methylation has been investigated in depth in vertebrate and plant genomes, establishing that it is involved in gene silencing and transposon control. Data regarding insect methylation, even if still scanty, apparently argue against evolutionary conservation of DNA methylation functions. Cytosine methylation, therefore, proves to be an epigenetic tool repeatedly used to accomplish different functions in different taxa according to a sort of epigenetic tinkering occurring during evolution.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available