Journal
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
Volume 28, Issue 4, Pages 412-416Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jpainsymman.2004.01.007
Keywords
malignant bowel obstruction; metoclopramide; octreotide; dexamethasone; amidotrizoato
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Early and intensive pharmacological treatment not only may reduce gastrointestinal symptoms but also reverse malignant bowel abstraction. fifteen consecutive advanced cancer patients with inoperable bowel obstruction received a combination of drugs including metoclopramide, octreotide, dexamethasone and an initial bolus of amidotrizoato. Recovery of intestinal transit was reported within 1-5 days in fourteen patients, who continued this treatment without presenting symptoms of bowel obstruction until death. This case series establishes that the combination of propulsive and antisecretive agents can act synergistically to allow a fast recovery of bowel transit without inducing unpleasant colic. It suggests that the most important mechanism in these circumstances is functional and can be reversible, if an aggressive treatment is initiated early before fecal impaction and edema render bowel obstruction irreversible. (C) 2004 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.
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