Journal
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
Volume 11, Issue 7, Pages 427-437Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jsgi.2004.04.001
Keywords
PROM; fetal membranes; apoptosis; MMPs; preterm labor
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Prematurity is the third leading cause of perinatal death, and preterm premature rupture of the membranes (pPROM) is associated with approximately 20-50% of all preterm births. The etiologic factors described for pPROM and preterm labor (PTL) are the same, although the clinical presentation (pPROM vs PTL) differs among patients. The reason-for this disparity is unknown and poses a therapeutic dilemma. Several etiologic factors have been described for PTL and pPROM. PTL and pPROM art, associated with overwhelming host inflammatory response. Many of these pro-inflammatory factors (inflammatory cytokine release) are common in both conditions; however, the clinical presentation differs The objective of this review is to explain the differential expression pattern of matrix metalloproteinases (MMPs) and pro-apoptotic elements in human fetal membranes in pPROM and PTL and how they interact to present different clinical outcomes during pregnancy. Copyright (C) 2004 by the Society for Gynecologic Investigation.
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