Journal
PHARMACOLOGY & THERAPEUTICS
Volume 104, Issue 1, Pages 17-27Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2004.07.006
Keywords
uptake; transporter; trafficking; regulation; internalization; endosome; recycling
Categories
Funding
- NIDA NIH HHS [R01 DA015169-04, DA 15169, DA 15355] Funding Source: Medline
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Sodium- and chloride-dependent transporters in the SLC6 gene family are key regulators of extracellular neurotransmitter levels and are required for normal neurotransmission. Copious evidence supports the premise that membrane trafficking dynamically modulates transporter surface expression in response to psychostimulant exposure, receptor activation, and neuronal activity. Recent work from our group and others demonstrates that many SLC6 transporters not only traffic in response to exogenous stimuli, but also constitutively traffic, with exogenous signaling modulating intrinsic transporter trafficking kinetics. This review focuses on what is currently understood about constitutive and regulated transporter trafficking, and poses a model wherein endocytic trafficking dynamically primes transporters for multifaceted regulatory events. (C) 2004 Elsevier Inc. All rights reserved.
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