Journal
BIOLOGICAL CHEMISTRY
Volume 385, Issue 10, Pages 865-872Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2004.113
Keywords
cell biology; electron microscopy; pattern recognition; proteomics; structural biology
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Cryoelectron tomography opens a window into the inner space of cells. It combines the potential of threedimensional imaging with a closetolife preservation of biological samples. Tomograms with molecular resolution are essentially images of the cellular proteome and, in conjunction with advanced pattern recognition techniques, they can be used to map the molecular landscape inside organelles and cells.
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