Journal
BEHAVIORAL NEUROSCIENCE
Volume 118, Issue 5, Pages 1071-1079Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.118.5.1071
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Funding
- NCRR NIH HHS [RR15565, G12RR03051, RR16470] Funding Source: Medline
- NIGMS NIH HHS [GM61838] Funding Source: Medline
- NIMH NIH HHS [MH019134-15] Funding Source: Medline
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A battery of behavioral tasks in C57BL/6J mice was used to assess changes in affective components of behavior after systemic exposure to the anabolic-androgenic steroid (AAS) 17alpha-methyltestosterone (7.5 mg/kg). Gonadal weight in both sexes was reduced after 16 days of AAS exposure. Changes in discrete components of social behaviors were observed. No changes were recorded in the elevated plus-maze, the fight-dark transition, and defensive behavior tests on exposure to 17a-methyltestosterone. When compared with controls, AAS-exposed females received a greater number of shocks, and AAS-exposed males displayed a shorter recovery time to consume water after a negative reinforcer in the modified Vogel conflict test. Results show that systemic exposure to a single AAS modified social behaviors, whereas minimal effects on anxiety-related behaviors were observed according to sex.
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