Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 19, Issue 10, Pages 1706-1711Publisher
WILEY
DOI: 10.1359/jbmr.2004.19.10.1706
Keywords
osteopontin; osteoclast; melanoma; tumor invasion; bone marrow ablation
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Tumor metastasis and invasion to bone is one of major medical issues in our modern societies. Osteopontin deficiency decreased tumor invasion in bone based on knockout mouse study. In bone, osteopontin is a positive factor to increase tumor invasion.
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