Journal
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
Volume 23, Issue 4, Pages 393-397Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.pgp.0000139655.18062.12
Keywords
ovary; neuroendocrine carcinoma; non-small cell type; endometrioid adenocarcinoma; hypercalcemia; parathyroid hormone (PTH)
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Ovarian tumors associated with hypercalcemia due to ectopic secretion of parathyroid hormone (PTH) are extremely rare. A 33-year-old woman presented with a pelvic mass and profound hypercalcemia accompanied by an elevated serum level of PTH. Laparotomy demonstrated a left ovarian tumor that on histological examination was a neuroendocrine carcinoma of non-small cell type admixed with a component of endometrioid adenocarcinoma. After left salpingo-oophorectomy, the serum calcium and PTH levels normalized. The cells of the neuroendocrine carcinoma were positive for neuron-specific enolase, synaptophysin, chromogranin A, and PTH. Hypercalcemia and elevated serum PTH levels recurred during tumor relapse, and the patient died of disease 6 months postoperatively. This is the eleventh case of neuroendocrine carcinoma of non-small cell type associated with surface epithelial neoplasm of the ovary, and the first such tumor to be associated with hypercalcemia.
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