Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 19, Issue 10, Pages 1712-1721Publisher
WILEY
DOI: 10.1359/JBMR.040703
Keywords
osteoprotegerin; TRAIL; prostate cancer; apoptosis; sRANKL; human bone marrow stromal cells
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Tumor-derived OPG has recently been shown to protect prostate cancer cells from apoptosis. This study has confirmed that bone marrow stromal cell-derived OPG also suppresses cytokine-induced apoptosis in this tumor type, suggesting that it may be the presence of bone-derived OPG that is responsible for the observed preference of these cells in colonizing the skeleton.
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