Journal
PROTEIN AND PEPTIDE LETTERS
Volume 11, Issue 5, Pages 423-432Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929866043406544
Keywords
ACE; angiotensin; disintegrin; hypertension; metalloproteinase; proteolysis; secretase; shedding
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Angiotensin-converting enzyme (ACE) is an example of a membrane-bound protein, which is shed from the cell Surface in a Soluble form by a post-translational proteolytic cleavage event involving a secretase. The secretase cleavage site in somatic ACE has been mapped to Arg-1203/Ser-1204. 24 residues proximal to the membrane-anchoring domain and the ADAM ('a disintegrin and metalloprotease') family of proteins may be involved in ACE shedding.
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