Journal
JOURNAL OF PARASITOLOGY
Volume 90, Issue 5, Pages 1184-1185Publisher
AMER SOC PARASITOLOGISTS
DOI: 10.1645/GE-308R
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Funding
- NIAID NIH HHS [AI-039075, AI-042362, AI-050228] Funding Source: Medline
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The nematode parasites Wuchereria bancrofti, Brugia malayi, and B. timori cause a human disease known as lymphatic filariasis, which afflicts approximately 120 million people worldwide. The parasites enter the human host from the mosquito as L3 or infective larvae and subsequently differentiate through 2 molts. In this communication, I report that B. malayi and B. pahangi depend on an exogenous source of at least 1 purine and 1 pyrimidine nucleoside to complete the L3 to L4 molt. The requirement for exogenous nucleosides opens the door for possible chemotherapeutic intervention.
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