Journal
CELL
Volume 119, Issue 1, Pages 9-18Publisher
CELL PRESS
DOI: 10.1016/j.cell.2004.09.020
Keywords
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIAID NIH HHS [R37 AI015706-27, R01 AI016892-27, AI-15067, R01 AI015706, R37 AI015706, R01 AI016892, AI-16892] Funding Source: Medline
- NIGMS NIH HHS [GM-499224, R01 GM049224-12, R01 GM049224, R01 GM101988] Funding Source: Medline
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Machines of protein destruction-including energy-dependent proteases and disassembly chaperones of the AAA+ ATPase family-function in all kingdoms of life to sculpt the cellular proteome, ensuring that unnecessary and dangerous proteins are eliminated and biological responses to environmental change are rapidly and properly regulated. Exciting progress has been made in understanding how AAA+ machines recognize specific proteins as targets and then carry out ATP-dependent dismantling of the tertiary and/or quaternary structure of these molecules during the processes of protein degradation and the disassembly of macromolecular complexes.
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