Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 69, Issue 20, Pages 6953-6956Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo0494477
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Zinc oxide (ZnO) brings about a rapid Friedel-Crafts acylation of a range of activated and unactivated aromatic compounds such as anisole and chlorobenzene with acid chlorides in solvent-free conditions at room temperature. The ZnO powder can be reused up to three times after simple washing with dichloromethane.
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