Journal
BIOLOGICAL CHEMISTRY
Volume 385, Issue 10, Pages 905-911Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2004.118
Keywords
genomic imprinting; microRNAs; noncoding RNAs; snoRNAs
Categories
Ask authors/readers for more resources
Genomic imprinting is an epigenetic phenomenon that results in differential expression of both alleles, depending on their parent of origin. We have recently identified many imprinted small noncoding RNA genes belonging to the C/D RNA and microRNA gene families, both of which are usually known to play key roles in posttranscriptional metabolism of specific genes (e.g. C/D RNAs guide ribose methylation of target RNAs while microRNAs elicit either translational repression or RNA interference). Although the functional and evolutionary significance of this association between C/D RNA genes, microRNA genes and genomic imprinting is still highly elusive, these observations provide a framework for further analysis of the potential role of small noncoding RNAs in epigenetic control.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available