Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 155, Issue 1-2, Pages 32-42Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2004.05.011
Keywords
EAE/MS; neuroimmunology; cell trafficking; adhesion molecules; cytokines
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Funding
- NCCIH NIH HHS [5 R21 AT001301-01] Funding Source: Medline
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Urate (UA) selectively scavenges peroxynitrite-dependent radicals and suppresses CNS inflammation through effects that are manifested at the blood-brain barrier (BBB).ICAM-1 upregulation in the spinal cord tissues of myelin basic protein (MBP) immunized mice is selectively inhibited by UA treatment. In contrast, the expression of ICAM-1 and other adhesion molecules by circulating cells is unchanged. Moreover, TNF-alpha expression in the CNS tissues of MBP-immunized mice is suppressed by UA treatment but TNF-alpha-induced ICAM-1 expression on neurovascular endothelial cells is not. Therefore the effect of UA on ICAM-1 upregulation in the CNS tissues is likely due to its known contribution to the maintenance of BBB integrity in MBP-immunized mice which in turn inhibits cell invasion into the CNS and prevents TNF-a production in CNS tissues. (C) 2004 Elsevier B.V. All rights reserved.
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