Journal
PHYTOTHERAPY RESEARCH
Volume 18, Issue 10, Pages 841-844Publisher
WILEY
DOI: 10.1002/ptr.1428
Keywords
Dictyophora indusiata; HMF and related analogues; tyrosinase inhibitor; noncompetitive inhibition
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The inhibition of mushroom tyrosinase by methanolic extract of Dictyophora indusiata was evaluated and the bioactive component was characterized and identified as 5-(hydroxymethyl)-2-furfural (HMF) by chromatographic and spectroscopic means. Kinetic studies revealed it to be a noncompetitive inhibitor for the oxidation of L-DOPA. On the basis of these findings some related analogues were also tested for their anti-tyrosinase activity, in order to gain more insight into structure and activity relationship among these heterocyclic compounds. Copyright (C) 2004 John Wiley Sons, Ltd.
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