Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 3, Issue 10, Pages 863-873Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd1521
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Complex glycans that are located at the surface of cells, deposited in the extracellular matrix and attached to soluble signalling molecules have a crucial role in the phenotypic expression of cellular genotypes. However, owing to their structural complexity and some redundancy in terms of structures that elicit a function, the therapeutic potential of complex glycans has not been well exploited, with a few notable exceptions. This review outlines recent advances that promise to increase our ability to use complex glycans as therapeutics. Opportunities for the development of further structure-function relationships for these complex molecules are also discussed.
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