Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 125, Issue 10-11, Pages 697-706Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2004.06.010
Keywords
glucocorticoids; glucocorticoid receptor (GR); NF-kappa B; AP-1
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Glucocorticoids are among the most widely prescribed anti-inflammatory drugs. They act by binding to the glucocorticoid receptor (GR) that, upon activation, translocates to the nucleus and either stimulates or inhibits gene expression. GR inhibition of many proinflammatory response genes occurs through induction of the synthesis of anti-inflammatory proteins as well as through repression of proinflammatory transcription factors, such as nuclear factor-kappaB (NF-kappaB) or activator protein-1 (AP-1). In this review, we discuss the molecular mechanisms underlying GR inhibition of inflammatory responses, with an emphasis on repression of NF-kappaB and AP-1 and their respective signaling pathways. Published by Elsevier Ireland Ltd.
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