Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 19, Issue 10, Pages 1698-1705Publisher
WILEY
DOI: 10.1359/JBMR.040709
Keywords
distraction osteogenesis; bisphosphonate; endochondral cartilaginous matrix; rabbit
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Bisphosphonates induce major increases in strength of callus in distraction osteogenesis in the short term. Poor understanding of the underlying mechanism, however, raises concerns about long-term consequences. In this long-term study in 32 rabbits, zoledronic acid transiently increased trabeculae by delayed temporal progression of endochondral bone remodeling but did not prevent radiographic completion of hope repair.
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