Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 69, Issue 20, Pages 6666-6673Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo049160+
Keywords
-
Categories
Ask authors/readers for more resources
A solid-phase procedure has been developed for the synthesis of chiral N-acylethylenediamine ligands. The ligands are obtained in good yield and purity, without the need for chromatography or other purification methods. Several new and previously reported ligands were prepared using this procedure. These compounds were examined as catalysts for the enantioselective addition of alkylzine reagents to aldehydes. In all cases, the crude ligands from the solid-phase syntheses catalyzed the reactions with similar yields and stereoselectivities when compared to reactions using ligands that had been purified by standard methods. Preliminary studies were also performed with ligands 3a and 3f as catalysts for the addition of alkenylzine reagents to aldehydes to give chiral allylic alcohols. Ligand 3f was found to catalyze this addition reaction in up to 76% ee.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available