Journal
AMERICAN JOURNAL OF HEMATOLOGY
Volume 77, Issue 2, Pages 200-202Publisher
WILEY
DOI: 10.1002/ajh.20160
Keywords
squamous cell carcinoma; tongue; GVHD; HSCT
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Two patients underwent allogeneic hematopoietic stem cell transplantation (HSCT) for acute myeloid leukemia. Chronic graft-versus-host disease (GVHD) developed, with persistent symptomatic oral lesions. At 2 and 6 years post-HSCT, both patients developed squamous cell carcinoma (SCC) of the tongue in areas previously involved by chronic GVHD. None had any known risk factor for SCC. Histologically, moderate to severe dysplasia was present in noncancerous oral mucosa. Oral SCC is rarely described after HSCT, and a review of the reported cases showed chronic GVHD to be a common risk, suggesting that the chronic inflammation associated with GVHD might be of pathogenetic significance. (C) 2004 Wiley-Liss, Inc.
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