Journal
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
Volume 204, Issue 2, Pages 125-133Publisher
TOHOKU UNIV MEDICAL PRESS
DOI: 10.1620/tjem.204.125
Keywords
Stanniocalcin 1 (STC-1); leukemia; real-time PCR; minimal residual disease (MRD)
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Stanniocalcin is a glycoprotein hormone that regulates the calcium level in fish. We found that mRNA of human stanniocalcin 1 (STC-1) is detectable in phytohemagglutimn-stimulated T cells and in most human leukemia cell lines, suggesting a role of STC-1 for cell proliferation. This finding prompts us to study the usefulness of STC-1 for monitoring acute leukemia. The levels of STC-1 transcripts increased in patients with acute leukemia at diagnosis and relapse, as judged by quantitative real-time RT-PCR. Levels of transcripts rapidly decreased to within the cut-off levels, when the blast numbers decreased with chemotherapy. Prolonged elevation of STC-1 levels after treatment was associated with a poor prognosis. All of 7 patients relapsed 1 to 4 months after they showed an elevated level of the transcripts in clinical remission. These results indicate that STC-1 is a novel marker for minimal residual disease of acute leukemia, and for an early diagnosis of relapse. (C) 2004 Tohoku University Medical Press.
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