Journal
NEUROBIOLOGY OF DISEASE
Volume 17, Issue 1, Pages 10-20Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2004.05.004
Keywords
Duchenne muscular dystrophy; cognitive impairment; spatial learning; water maze; object recognition; mutant mice; long-term potentiation (LTP)
Categories
Ask authors/readers for more resources
Duchenne muscular dystrophy (DMD) is associated with cognitive deficits that may result from dystrophin deficiency in neurons. However, in the dystrophin-deflcient Dmd(mdx) mouse model of DMD, the nature of the memory impairment is not well characterised and its biological substrate is uncertain. Here, we demonstrate that dystrophin deficiency in Dmd(mdx) mice impairs long-term, but not short-term, object recognition memory and impairs long-term spatial memory, but not acquisition, following massed training in the water maze. Furthermore, we show that the abnormal enhancement of CA1 hippocampal LTP in Dmd(mdx) mice is not restricted to short-lasting mechanisms, but also affects the maintenance phase of UP of both synaptic efficacy and neuronal excitability. We conclude that dystrophin loss alters memory consolidation in both spatial and nonspatial learning tasks, at least in part due to altered synaptic plasticity mechanisms, and suggest that the severity ofthe deficits may depend on the nature of the training procedure. (C) 2004 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available