Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 27, Issue 10, Pages 1584-1587Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.27.1584
Keywords
aldose reductase inhibitor; sorbitol accumulation; ellagic acid; 2-(2,3,6-trihydroxy-4-carboxyphenyl)ellagic acid; diabetes; Caesalpinia ferrea
Categories
Ask authors/readers for more resources
Caesalpinia ferrea Mart. (Leguminosae) called as JucA is one of the medicinal plants in Brazil used for diabetes. From the fruits of this plant, ellagic acid (EA) and 2-(2,3,6-trihydroxy-4-carboxyphenyl)ellagic acid (TEA) have been recently isolated as aldose reductase (AR) inhibitors. In this study, we examined to prove the inhibitory activity against AR of EA and TEA in vitro, and EA in vivo by measurement of the accumulation of sorbitol, which is the product of glucose reduction catalyzed by AR. TEA was not examined in vivo because of its shortage of yield from the fruits. EA and TEA significantly and dose-dependently inhibited sorbitol accumulation in erythrocytes, lens and sciatic nerve under incubating with glucose in vitro. EA at a dose of 75 mg/kg/d showed the most potent inhibition of sorbitol accumulation in erythrocytes, lens and sciatic nerve at 50, 75 and 100 mg/kg/d in vivo. These results suggest that the inhibitory activity of EA against AR causes to inhibit sorbitol accumulation by in vitro and in vivo experiments. EA is distributed in fruits and vegetables, so that taking them might be able to relieve diabetic complications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available