Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 14, Issue 5, Pages 533-539Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2004.07.013
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Funding
- NINDS NIH HHS [R01 NS073159] Funding Source: Medline
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The Wnt signaling pathway plays essential roles in embryogenesis of higher eukaryotes from diploblastic, radially symmetrical cnidarians to mice and humans. Whereas studies in model organisms such as Drosophila and Xenopus continue to elucidate how the Writ pathway is regulated, studies of mouse mutants and cultured mammalian cells start to reveal how the Writ pathway controls development and differentiation in mammals. Here we review some of the recent progresses in our understanding of the Writ pathway. We focus on how this pathway, through regulating transcription of its downstream target genes, specifies pattern formation during mammalian embryogenesis and functions in the differentiation and maintenance of stem cells both in vivo and in vitro.
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