Journal
ANTI-CANCER DRUGS
Volume 15, Issue 9, Pages 825-833Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001813-200410000-00002
Keywords
arginine; cancer; catabolic enzymes; cell cycle; citrulline; cell death; deprivation; pegylation; therapy
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Interest has recently been revived in enzymes that degrade essential amino acids. Arginine-catabolizing enzymes now predominate and are discussed in this review. Apart from reducing tumor load through cell death occurring as a result of deprivation alone, these catabolic enzymes conveniently leave the remaining malignant cells vulnerable to other therapeutic modalities through combinatorial treatments with cycle-dependent drugs, the timing of additional treatment after deprivation being crucial. (C) 2004 Lippincott Williams Wilkins.
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