Journal
SEMINARS IN CANCER BIOLOGY
Volume 14, Issue 5, Pages 348-356Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2004.04.014
Keywords
notch signaling; mastermind; transcriptional co-activator; Mucoepidermoid carcinoma; cervical cancer
Categories
Funding
- NCI NIH HHS [R01 CA36167, R01 CA097148] Funding Source: Medline
Ask authors/readers for more resources
Notch signaling is mediated by cell-cell interactions and is critical for cell fate determination in many species. Recently, a family of mastermind-like (MAML) transcriptional co-activator genes was identified that encode proteins that cooperate with Notch and CSL to activate transcription. Here, we review our current understanding of the roles of the MAML proteins in Notch signaling, and their involvement in certain human cancers. The mounting biochemical and functional evidence indicate that the MAML genes are critical components of the Notch signaling pathway, likely regulating cellular events involved in both normal development and oncogenesis. (C) 2004 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available