Journal
NEUROLOGICAL RESEARCH
Volume 26, Issue 7, Pages 792-796Publisher
MANEY PUBLISHING
DOI: 10.1179/016164104225014148
Keywords
securinine; beta-amyloid protein; GABA; neuroprotection
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The effects of (+) securinine on behavior and morphological changes after intracerebral ventricle injection of beta-amyloid (25-35) (Abeta(25-35)) in rats were investigated. A single high dose of Abeta((25-35)) could impair the spatial cognitive function. The latency of locating the platform was longer in the model group than in the sham-operated group. While chronic administration of D-securinine (40 mg kg(-1)) could significantly shorten the latency. After Morris water maze, the activity of choline acetyltransferase (ChAT) and acetylcholinesterase (AchE) were detected. The results showed that D-securinine could decrease the AchE activity significantly and have no effect on ChAT. Meanwhile, immunohistochemistry analysis revealed that D-securinine could reduce the glial inflammatory responses induced by beta-amyloid protein. These results suggest that the effect Of D-securinine in improving the cognitive deficits and neurodegeneration in betaAP(25-35) treated rats may involve direct and indirect actions on targets. The GABA receptor plays a key role in them terapeutic effects and may be helpful in the treatment of Alzheimer's disease.
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