Journal
PHYSIOLOGICAL REVIEWS
Volume 84, Issue 4, Pages 1315-1339Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physrev.00002.2004
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- NIGMS NIH HHS [R01 GM047607] Funding Source: Medline
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Molecular scaffold or adaptor proteins facilitate precise spatiotemporal regulation and integration of multiple signaling pathways to effect the optimal cellular response to changes in the immediate environment. Paxillin is a multidomain adaptor that recruits both structural and signaling molecules to focal adhesions, sites of integrin engagement with the extracellular matrix, where it performs a critical role in transducing adhesion and growth factor signals to elicit changes in cell migration and gene expression.
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