Journal
BRITISH JOURNAL OF CANCER
Volume 91, Issue 7, Pages 1380-1383Publisher
SPRINGERNATURE
DOI: 10.1038/sj.bjc.6602125
Keywords
lung carcinogenesis; benzo[alpha] pyrene; resveratrol; adducts; CYP1A1; CYP1B1
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Resveratrol inhibits PAH bioactivation through reduced expression of the CYP1A1 and CYP1B1 genes in human bronchial epithelial cells. Ad libitum access to a diet containing resveratrol showed no effect on benzo[ a] pyrene-induced lung tumorigenesis in A/J mice. Also, resveratrol did not change CYP1A1 and CYP1B1 gene expression or benzo[ a] pyrene protein adduct levels in the lung tissue. The lack of chemopreventive activity may have been caused by insufficient concentrations or nonreactive forms of resveratrol in the lungs.
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