Journal
FEBS LETTERS
Volume 576, Issue 1-2, Pages 27-30Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2004.08.056
Keywords
ratjadone; leptomycin; chromosomal region maintenance 1; nuclear export
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Research on the export of proteins and nucleic acids from the nucleus to the cytoplasm has greatly gained from the discovery that the actinobacterial toxin leptomycin B (LMB) specifically inactivates the export receptor chromosomal region maintenance 1 (CRM1). Recently, it was shown that myxobacterial cytotoxins, named ratjadones (RATs), also bind to CRM1 and inhibit nuclear export. However, the reaction mechanism of RATs was not resolved. Here, we show that LMB and RAT A employ the same molecular mechanism to inactivate CRM1. Alkylation of residue Cys528 of CRM1 determines both LMB and RAT sensitivity and prevents nuclear export of CRM1 cargo proteins. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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