Journal
FEBS LETTERS
Volume 576, Issue 1-2, Pages 73-76Publisher
WILEY
DOI: 10.1016/j.febslet.2004.08.064
Keywords
Ca2+-ATPase; sarcoplasmic reticulum; inhibition; CPA; Ca2+ -binding; coupling factor
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The mycotoxin cyclopiazonic acid (CPA) is a potent inhibitor of the sarcoplasmic reticulum Ca2+-ATPase. The compound decreases the affinity of the Ca2+-ATPase for Ca2+ and reduces the maximum specific activity of the enzyme. Furthermore, CPA abolishes the cooperativity of Ca2+ transport, showing a Ca2+/ATP ratio similar to1 at any extent of Ca2+ saturation. There is also an effect on the Ca2+-binding mechanism, where the addition of CPA results in binding of only half-maximal amount of Ca2+ observed in its absence. The experimental data suggest that in the presence of CPA, only a single Ca2+ ion binds to the Ca2+-ATPase. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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