Journal
FEBS LETTERS
Volume 576, Issue 1-2, Pages 107-113Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2004.08.072
Keywords
C center dot reactive protein; glycosylated human C-reactive protein; molecular variant; phosphorylcholine; protein A binding; Staphylococcus aureus cell-surface protein A
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Phosphorylcholine (PC) is a classical ligand of C-reactive protein (CRP), a clinically important acute phase protein. In search of new ligands, CRPs were affinity-purified from several pathological samples, which exhibited distinct molecular variants induced in different diseases. Both glycosylated and non-glycosylated CRPs showed calcium-independent differential-binding to Staphylococcus aureus cell-surface Protein A. CRP possesses separate binding sites for Protein A and PC with different binding constants. We have demonstrated that Protein A is another ligand in addition to PC establishing an extended definition of CRP. Protein A binding may impart immunomodulatory roles of CRP in combating microorganisms or other foreign materials. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B V. All rights reserved.
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