Journal
FEBS LETTERS
Volume 576, Issue 1-2, Pages 245-250Publisher
WILEY
DOI: 10.1016/j.febslet.2004.08.077
Keywords
map-1; map-2; methionine aminopeptidase; germline development
Funding
- NCI NIH HHS [CA078743] Funding Source: Medline
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We have investigated the physiological function of type 2 methionine aminopeptidases (MetAP2) using Caenorhabditis elegans as a model system. A homolog of human MetAP2 was found in the C. elegans genome, which we termed MAP-2. MAP-2 protein displayed methionine aminopeptidase activity and was sensitive to inhibition by fumagillin. Downregulation of map-2 expression by RNAi led to sterility, resulting from a defect in germ cell proliferation. These observations suggest that MAP-2 is essential for germ cell development in C elegans and that this ubiquitous enzyme may play important roles in a tissue specific manner. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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