Journal
SCIENCE
Volume 306, Issue 5695, Pages 485-487Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1099288
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Funding
- NCI NIH HHS [N01-CO-124000] Funding Source: Medline
- NIAID NIH HHS [AI 51649, AI 36219] Funding Source: Medline
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Topical agents, such as microbicides, that can protect against human immunodeficiency virus (HIV) transmission are urgently needed. Using a chimeric simian/human immunodeficiency virus (SHIV SF162), which is tropic for the chemokine receptor CCR5, we report that topical application of high doses of PSC-RANTES, an amino terminus-modified analog of the chemokine RANTES, provided potent protection against vaginal challenge in rhesus macaques. These experimental findings have potentially important implications for understanding vaginal transmission of HIV and the design of strategies for its prevention.
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