Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 343, Issue 2, Pages 407-416Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2004.08.018
Keywords
BACE; crystallography; drug discovery; Alzheimer's disease
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Human BACE, also known as beta-secretase, shows promise as a potential therapeutic target for Alzheimer's disease. We determined the apo structure of BACE to 1.75 Angstrom, and a structure of a hydroxyethylamine inhibitor complex derived by soaking. These show significant active-site movements compared to previously described BACE structures. Additionally, the structures reveal two pockets that could be targeted by structure-based drug design. (C) 2004 Elsevier Ltd. All rights reserved.
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