Journal
SCIENCE
Volume 306, Issue 5695, Pages 487-491Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1100135
Keywords
-
Categories
Funding
- NINDS NIH HHS [NS30658] Funding Source: Medline
Ask authors/readers for more resources
Long-term memory is thought to be mediated by protein synthesis-dependent, late-phase tong-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and brain-derived neurotrophic factor (BDNF), have been implicated in this process, but their relationship is unclear. Here we report that tPA, by activating the extracellular protease plasmin, converts the precursor proBDNF to the mature BDNF (mBDNF), and that such conversion is critical for L-LTP expression in mouse hippocampus. Moreover, application of mBDNF is sufficient to rescue L-LTP when protein synthesis is inhibited, which suggests that mBDNF is a key protein synthesis product for L-LTP expression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available