Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 200, Issue 8, Pages 979-990Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20041061
Keywords
Helicobacter pylori; phase variation; DC-SIGN; dendritic cells; Th1/Th2 cell response
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The human gastric pathogen Helicobacter pylori spontaneously switches lipopolysaccharide (LPS) Lewis (Le) antigens on and off (phase-variable expression), but the biological significance of this is unclear. Here, we report that Le(+) H. pylori variants are able to bind to the C-type lectin DC-SIGN and present on gastric dendritic cells (DCs), and demonstrate that this interaction blocks T helper cell (Th)1 development. In contrast, Le(-) variants escape binding to DCs and induce a strong Th1 cell response. In addition, in gastric biopsies challenged ex vivo with Le(+) variants that bind DC-SIGN, interleukin 6 production is decreased, indicative of increased immune suppression. Our data indicate a role for LPS phase variation and Le antigen expression by H. pylori in suppressing immune responses through DC-SIGN.
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