Journal
CHEMICAL COMMUNICATIONS
Volume -, Issue 20, Pages 2260-2261Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b411973h
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PCR primers designed to selectively amplify the unique C-methyltransferase domain of fungal Polyketide synthases were used to selectively clone a polyketide synthase gene involved in the biosynthesis of the squalene synthase inhibitor squalestatin S1 1, heterologous expression of which led to the biosynthesis of the squalestatin side-chain.
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