Journal
VACCINE
Volume 22, Issue 31-32, Pages 4385-4389Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2004.01.073
Keywords
transgenic plant; oral vaccine; E. coli
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Funding
- NCRR NIH HHS [M01 RR165001] Funding Source: Medline
- NIAID NIH HHS [N01-AI-65299] Funding Source: Medline
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Previous clinical studies have demonstrated the feasibility of using edible transgenic plants to deliver protective antigens as new oral vaccines. Transgenic corn is particularly attractive for this purpose since the recombinant antigen is stable and homogeneous, and corn can be formulated in several edible forms without destroying the cloned antigen. Transgenic corn expressing 1 mg of LT-B of Escherichia coli without buffer was fed to adult volunteers in three doses, each consisting of 2.1 g of plant material. Seven (78%) of nine volunteers developed rises in both serum IgG anti-LT and numbers of specific antibody secreting cells after vaccination. Four (44%) of nine volunteers also developed stool IgA. Transgenic plants represent a new vector for oral vaccine antigens. (C) 2004 Elsevier Ltd. All rights reserved.
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