Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1053, Issue 1-2, Pages 7-14Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2004.06.046
Keywords
reviews; proteomics; proteins
Funding
- NCRR NIH HHS [RR11823-08] Funding Source: Medline
- NIMH NIH HHS [5 R01 MH067880] Funding Source: Medline
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The global identification of post-translationally modified proteins is a difficult challenge that is currently being addressed by many researchers in the field of mass spectrometry (MS)-based proteomics. The ability to identify thousands of proteins by shotgun-based strategies has made the mere idea of a global analysis of a particular protein modification seem reasonable. There has been much progress in the development of methods that make use of shotgun-based protein identification in the analysis of a wide variety of protein modifications, some of which will be discussed here. (C) 2004 Elsevier B.V. All rights reserved.
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