Journal
ORGANIC LETTERS
Volume 6, Issue 22, Pages 4109-4112Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol0481784
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We have developed, on the basis of a chelation-strategy, an efficient copper-catalyzed aziridination protocol with the use of 5-methyl-2-pyridinesulfonamide and Phl(OAc)(2). The reaction proceeds smoothly under mild conditions to give aziridines in moderate to good yields in the absence of external ligands or bases. The coordination-assisted approach offers the additional benefits that efficient deprotection of the N-substituent and selective aziridine ring-opening are effectively achieved.
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