4.8 Article

Total synthesis of eupomatilones 4 and 6: Structurally rearranged and atropisomerically fluxional lignan natural products

Journal

ORGANIC LETTERS
Volume 6, Issue 22, Pages 4025-4028

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol048333e

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Funding

  1. NCI NIH HHS [R01 CA 91904] Funding Source: Medline

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A convergent and diastereocontrolled total synthesis of eupomatilones 4 and 6 is reported and was based on a diastereoselective hydroboration/oxidation sequence and a convergent Lipshutz biarylcuprate cross-coupling reaction. The structure of eupomatilone 6 is revised.

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