Journal
BRAIN RESEARCH
Volume 1025, Issue 1-2, Pages 226-230Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2004.08.005
Keywords
aging; susceptibility to ischemia; oxygen and glucose deprivation; hippocampal slice; LDH release; MTT; DCF
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Aging is an important risk factor for stroke. We evaluated the effects of aging on cell susceptibility to oxygen and glucose deprivation (OGD) in slices of the hippocampus from Wistar rats aged 2, 11 and 24 months. Lactate dehydrogenase (LDH) released to the incubation media and free radical content were markedly increased in the 24-month group submitted to OGD. These results confirm that hippocampal tissue from old animals is more susceptible to ischemia-reoxygenation injury. (C) 2004 Elsevier B.V. All rights reserved.
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