Journal
SCIENCE
Volume 306, Issue 5697, Pages 879-881Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1101678
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Reduced serotonin transporter (5-HTT)-expression is associated with abnormal affective and anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown. Transient inhibition of 5-HTT during early development with ftuoxetine, a commonly used serotonin selective reuptake inhibitor, produced abnormal emotional behaviors in adult mice. This effect mimicked the behavioral phenotype of mice genetically deficient in 5-HTT expression. These findings indicate a critical rote of serotonin in the maturation of brain systems that modulate emotional function in the adult and suggest a developmental mechanism to explain how low-expressing 5-HTT promoter alleles increase vulnerability to psychiatric disorders.
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