Journal
PHYTOTHERAPY RESEARCH
Volume 18, Issue 11, Pages 954-956Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/ptr.1589
Keywords
Momordica charantia; oral glucose tolerance; triglyceride; cholesterol; high density lipoprotein; low density lipoprotein
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In this study, the methanol extract of Homordica charantia fruit extract was administered to diabetic rats to assess the long term effect of the extract on the lipid profile and the oral glucose tolerance test. Treatment for 30 days showed a significant decrease in triglyceride, low density lipoprotein and a significant increase in high density lipoprotein level. A significant effect on oral glucose tolerance was also noted. Chronic administration showed an improvement in the oral glucose tolerance curve. The effect was more pronounced when the test was done in rats fed the extract on the day of the test compared with tests done in rats which were not fed the extract on the same day. Copyright (C) 2004 John Wiley Sons, Ltd.
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